Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells
نویسندگان
چکیده
منابع مشابه
Regulation of phospholipase C isozymes by ras superfamily GTPases.
The physiological effects of many extracellular stimuli are mediated by receptor-promoted activation of phospholipase C (PLC) and consequential activation of inositol lipid-signaling pathways. These signaling responses include the classically described conversion of PtdIns(4,5)P(2) to the Ca(2+)-mobilizing second messenger Ins(1,4,5)P(3) and the protein kinase C-activating second messenger diac...
متن کاملEvolution and Diversity of the Ras Superfamily of Small GTPases in Prokaryotes
The Ras superfamily of small GTPases are single domain nucleotide-dependent molecular switches that act as highly tuned regulators of complex signal transduction pathways. Originally identified in eukaryotes for their roles in fundamental cellular processes including proliferation, motility, polarity, nuclear transport, and vesicle transport, recent studies have revealed that single domain GTPa...
متن کاملBiochemical Clustering of Monomeric GTPases of the Ras Superfamily*□S
To date phylogeny has been used to compare entire families of proteins based on their nucleotide or amino acid sequence. Here we developed a novel analytical platform allowing a systematic comparison of protein families based on their biochemical properties. This approach was validated on the Rho subfamily of GTPases. We used two high throughput methods, referred to as AlphaScreen and FlashPlat...
متن کاملBiochemical clustering of monomeric GTPases of the Ras superfamily.
To date phylogeny has been used to compare entire families of proteins based on their nucleotide or amino acid sequence. Here we developed a novel analytical platform allowing a systematic comparison of protein families based on their biochemical properties. This approach was validated on the Rho subfamily of GTPases. We used two high throughput methods, referred to as AlphaScreen and FlashPlat...
متن کاملActivation of the Ras superfamily of small GTPases. Workshop on exchange factors.
Introduction The Center for International Meetings on Biology workshop on ‘Exchange Factors’ provided an up-to-date view of how guaninenucleotide-exchange factors (GEFs) affect the biochemical pathways that regulate the Ras superfamily of small GTPases, and how these molecules function as part of an interrelated network of regulatory proteins that mediate the biological responses of Ras-like GT...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2019
ISSN: 2154-1248,2154-1256
DOI: 10.1080/21541248.2019.1665968